as far as I’m aware you currently can’t disable those notifications.
The only way to “disable” them is to disable your E-Mail-Notification for escalated E-Mails (or) work your reminders away, before Zammad can bug you with it’s reminder.
For this you could use a trigger (or scheduler) that runs at about let’s say 10-11pm UTC that resets all pending reminders reached back to open or another own custom state.